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The NSF-Simons Center for Multiscale Cell Fate Research (CMCF) is connecting scientists across the physical and biological sciences to usher in a new era of biology.


Cells, the building blocks of life, are complex machines constructed from genetic blueprints that are strongly influenced by their in vivo environment. Recent advances in single cell measurement indicate that cells are more heterogeneous, with vastly more unknown types, than previously recognized, and that cell fate decisions are stochastic, dynamic, and complex. Massive genomic data at the single-cell scale are beginning to reveal new complex genotypes, while live imaging of cells in space shows novel phenotypes and unresolved functions in dynamic environments.

These newly-observed heterogeneities and the associated stochastic transitions are challenging how we define cell fate. Measurements of noise and epigenetic regulation suggest the importance of other previously unexplored layers of complexity driving cell fate decisions. It is increasingly clear that experimental tools alone are insufficient to dissect cell fate, and mathematical, statistical, and computational approaches are becoming indispensable to revealing cell fate: an emergent property arising from complex interactions among biochemical and physical events across temporal and spatial scales within and outside cells.

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UPCOMING EVENTS

The 1st annual center symposium will be held on October 1-2nd 2018 at the Beckman Center of the National Academies of Sciences and Engineering. Conference details.

On July 26-27th, CMCF hosted a mechanobiology symposium: The Mechanome in Action.

More Events at CMCF

UPCOMING EVENTS

The 1st annual center symposium will be held on October 1-2nd 2018 at the Beckman Center of the National Academies of Sciences and Engineering. Conference details.

CMCF hosts a mechanobiology symposium: The Mechanome in Action, July 26-27. More details.

More Events

OPEN POSITIONS

We are recruiting! Opportunities to join the center as an NSF-Simons Postdoctoral Fellow are open now. Successful candidates will work with center faculty members to carry out interdisciplinary research projects on cell fate dynamics.

Candidates with training/experience in modeling, informatics, or experimental biology are all welcome to apply. Full details and application portal are available here.