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The NSF-Simons Center for Multiscale Cell Fate Research (CMCF) is connecting scientists across mathematical, physical, and biological sciences to usher in a new era of biology. CMCF is one of four NSF-Simons Research Centers for Mathematics of Complex Biological Systems situated across the country, jointly funded by the National Science Foundation and the Simons Foundation.

Cells, the building blocks of life, are complex machines constructed from genetic blueprints that are strongly influenced by their in vivo environment. Recent advances in single cell measurement indicate that cells are more heterogeneous, with vastly more unknown types, than previously recognized, and that cell fate decisions are stochastic, dynamic, and complex. Massive genomic data at the single-cell scale are beginning to reveal new complex genotypes, while live imaging of cells in space shows novel phenotypes and unresolved functions in dynamic environments.

These newly-observed heterogeneities and the associated stochastic transitions are challenging how we define cell fate. Measurements of noise and epigenetic regulation suggest the importance of other previously unexplored layers of complexity driving cell fate decisions. It is increasingly clear that experimental tools alone are insufficient to dissect cell fate, and mathematical, statistical, and computational approaches are becoming indispensable to revealing cell fate: an emergent property arising from complex interactions among biochemical and physical events across temporal and spatial scales within and outside cells.

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BioBridge Clinic applications are now closed.

NSF-Simons Center for Multiscale Cell Fate (CMCF) will have a one-week BioBridge Clinic in conjunction with the Systems Biology Short Course at UCI.

The BioBridge clinic will provide an accessible entry point for mathematical scientists who wish to receive an introduction to biological theory and practice. It will include hands-on experiments as well as introductory lectures in molecular, cellular, and developmental biology, providing exposure to a range of experimental model systems. The BioBridge Clinic is open only to PhD students and postdoctoral fellows.

The first BioBridge Clinic will take place the week of January 20, 2019. There will be a $400 registration fee for the one-week Clinic, which will include breakfast and lunch. Four Clinic fellowships, with each up to $900, will be provided to successful applicants. The deadline to submit an application was November 30, 2018 however check back next year for the 2020 BioBridge Clinic!

For questions, please contact .



Applications are invited for three faculty position openings at University of California, Irvine (UCI). We seek candidates with research interests related to the broad themes of the NSF-Simons Center for Multiscale Cell Fate Research. The three faculty positions are hosted at three different departments at UCI. Each position opening has a different application link and a slightly different deadline:

  • Mathematics or/and Physics (by 11/15/2018): Apply here
  • Statistics (by 11/1/2018): Apply here
  • Developmental and Cell Biology (by 11/30/2018): Apply here

If you have any questions on the positions, please email to the contact person listed in each search link or .



We are recruiting! Opportunities to join the center as an NSF-Simons Postdoctoral Fellow are open now. Successful candidates will work with center faculty members to carry out interdisciplinary research projects on cell fate dynamics.

Candidates with training/experience in modeling, informatics, or experimental biology are all welcome to apply. Full details and application portal are available here.